| D. DouděraDefensive midfielder | FC Cincinnati | 🇨🇿Czechia | 28 | 22 | 1 | 4 | 7.2 | 18 | 1 |
| D. DownsWinger |  St. Louis City | 🇩🇪Germany | 22 | 4 | 0 | 0 | 6.4 | 3 | 59▼7.9%↩ |
| D. EdelmanCentral midfielder | St. Louis City | 🇺🇸USA | 23 | 25 | 4 | 3 | 15.4 | 50▲122.4%↩ | 50▲18.2%↩ |
| D. EtienneCentre-forward |  Toronto FC | 🇭🇹Haiti | 29 | 21 | 4 | 1 | 3.8 | 23▲91% | 26▲7.4% |
| D. FagundezCentral midfielder |  New England Revolution | 🇺🇾Uruguay | 31 | 14 | 0 | 0 | 1.3 | 2▼95.7%↩ | 15▼36.1%↩ |
| D. FerreeGoalkeeper |  San Diego | 🇺🇸USA | 19 | 15 | 0 | 0 | 6.4 | 18 | 43 |
| D. GarcíaCentral midfielder |  FC Dallas | 🇺🇸USA | 19 | 2 | 0 | 0 | 5.6 | 0 | 37 |
| D. GazdagCentre-forward | New England Revolution | 🇭🇺Hungary | 30 | 18 | 3 | 0 | 1.8 | 0▼100%↩ | 16▼37.8%↩ |
| D. HolmesDefensive midfielder |  Houston Dynamo | 🇺🇸USA | 31 | 15 | 0 | 0 | 1.5 | 9▲8.7% | 18▲12.7% |
| D. Jean-JacquesCentral midfielder |  Philadelphia Union | 🇭🇹Haiti | 26 | 25 | 4 | 2 | 13.2 | 51▲37.4% | 43▲8.4% |
| D. JohnsonCentral midfielder |  San Jose Earthquakes | 🇬🇩Grenada | 26 | 4 | 0 | 0 | 5.7 | 1▼70.4%↩ | 30▲14.4%↩ |
| D. JonesCentre-back | San Jose Earthquakes | 🇺🇸USA | 29 | 5 | 0 | 0 | 2.3 | 8▼29.5% | 22▼15.6% |
| D. JoveljićCentre-forward |  Seattle Sounders | 🇷🇸Serbia | 27 | 21 | 10 | 1 | 6.4 | 13▼78.7%↩ | 31▼19.7%↩ |
| D. LasGoalkeeper |  Austin | 🇺🇸USA | 24 | 1 | 0 | 0 | 6.1 | 0▼100%↩ | 32▼2.4%↩ |
| D. LovitzCentre-back |  Nashville SC | 🇺🇸USA | 35 | 26 | 0 | 1 | 1.3 | 47▲41.9% | 15▼12.4% |
| D. LunaAttacking midfielder |  Real Salt Lake | 🇺🇸USA | 23 | 18 | 5 | 3 | 9.6 | 34▼6% | 45▼4.1% |
| D. MarczukCentre-forward | Real Salt Lake | 🇵🇱Poland | 22 | 12 | 1 | 0 | 6.6 | 6▼38.4% | 38▼4.1% |
| D. McGuireCentre-forward | Houston Dynamo | 🇺🇸USA | 25 | 14 | 2 | 0 | 7 | 0▼100%↩ | 36▼3.7%↩ |
| D. MihailovićCentre-forward | Toronto FC | 🇺🇸USA | 27 | 12 | 2 | 5 | 7 | 25▼35.9%↩ | 34▼9.2%↩ |
| D. MunieCentre-back | San Jose Earthquakes | 🇺🇸USA | 26 | 24 | 4 | 1 | 8.7 | 26▲56.4% | 42▲14.9% |
| D. MusovskiCentre-forward | Seattle Sounders | 🇺🇸USA | 30 | 19 | 1 | 0 | 1.9 | 8▼82.7% | 21▼20.1% |
| D. NealisCentre-back |  New York Red Bulls | 🇺🇸USA | 28 | 22 | 0 | 0 | 4.2 | 20▲33.3% | 32▲17.9% |
| D. NelichWinger | New York Red Bulls | 🏳️ | 17 | 2 | 0 | 0 | 4.8 | 0 | 37 |
| D. OdleGoalkeeper | New York Red Bulls | 🇺🇸USA | 25 | 0 | 0 | 0 | 6 | 0 | 32 |
| D. PadelfordFull-back | New York Red Bulls | 🇺🇸USA | 23 | 18 | 1 | 1 | 6.8 | 1▼90.8%↩ | 34▼4.5%↩ |
| D. PereiraCentral midfielder |  CF Montreal | 🇻🇪Venezuela | 26 | 15 | 0 | 1 | 6.2 | 5▼82.3%↩ | 33▼17.5%↩ |
| D. PhillipCentre-forward |  Colorado Rapids | 🏳️ | 21 | 7 | 1 | 0 | 6.6 | 0 | 36 |
| D. PolvaraCentre-back | St. Louis City | 🇺🇸USA | 26 | 26 | 1 | 0 | 9.3 | 31▲130.6%↩ | 42▲17.2%↩ |
| D. PorębaAttacking midfielder |  Chicago Fire | 🇺🇸USA | 23 | 1 | 0 | 1 | 7 | 3▲1300%↩ | 37▲18.1%↩ |
| D. RíosCentre-forward | CF Montreal | 🇲🇽Mexico | 31 | 22 | 4 | 0 | 2.5 | 15▼19.9%↩ | 18▼12%↩ |
| D. RomneyCentre-back | San Jose Earthquakes | 🇺🇸USA | 33 | 15 | 1 | 0 | 1.3 | 10▼35.8% | 12▼35.4% |
| D. RuízCentral midfielder | New York Red Bulls | 🇭🇳Honduras | 22 | 10 | 0 | 0 | 6.3 | 0▼100%↩ | 35▲1.1%↩ |
| D. SallóiAttacking midfielder | Toronto FC | 🇭🇺Hungary | 30 | 26 | 7 | 6 | 4.7 | 45▲41.1%↩ | 30▲18.7%↩ |
| D. SamassékouDefensive midfielder | Houston Dynamo | 🇲🇱Mali | 30 | 22 | 0 | 0 | 2.1 | 11 | 22▲43.2% |
| D. SchneggFull-back |  Charlotte | 🇦🇹Austria | 27 | 17 | 1 | 3 | 6.8 | 12▼59.1%↩ | 33▼9.2%↩ |
| D. SealyWinger | CF Montreal | 🇺🇸USA | 23 | 21 | 0 | 2 | 6.7 | 0▼100% | 34▼25.3% |
| D. St. ClairGoalkeeper |  Inter Miami | 🇨🇦Canada | 29 | 21 | 0 | 0 | 3 | 7▼70.5%↩ | 29▼7.9%↩ |
| D. TaylorCentre-back |  Minnesota United FC | 🇺🇸USA | 29 | 4 | 0 | 0 | 2 | 1▼66.7% | 20▼7.1% |
| D. TevesCentral midfielder | Seattle Sounders | 🇺🇸USA | 26 | 0 | 0 | 0 | 5.2 | 0▼100% | 28▼21.6% |
| D. ToureCentre-forward | Colorado Rapids | 🇺🇸USA | 22 | 0 | 0 | 0 | 6.2 | 0 | 35▼4.7% |
| D. TurgemanCentre-forward | New England Revolution | 🇮🇱Israel | 22 | 26 | 7 | 7 | 14.5 | 44▲412.9% | 49▲17.5% |
| D. VazquezCentral midfielder | San Diego | 🇺🇸USA | 20 | 18 | 3 | 0 | 8.4 | 25▲2350% | 43▲9.8% |
| D. YapiWinger | Colorado Rapids | 🇺🇸USA | 21 | 26 | 3 | 2 | 7.7 | 23▼19.4% | 46▲3.9% |
| D. YedlinFull-back | Real Salt Lake | 🇺🇸USA | 33 | 18 | 0 | 1 | 1.4 | 11▼52%↩ | 14▼9.2%↩ |
| D. ÞórhallssonFull-back | San Diego | 🇮🇸Iceland | 26 | 31 | 3 | 0 | 6 | 2▼82.1%↩ | 31▼12.5%↩ |
| D.RosalesCentre-back |  Los Angeles FC | 🇺🇸USA | 20 | 0 | 0 | 0 | 5.7 | 0 | 37 |
| DanielGoalkeeper | FC Dallas | 🇧🇷Brazil | 32 | 17 | 0 | 0 | 1.1 | 0▼100%↩ | 12▼42%↩ |
| Daniel PinterCentre-forward | Inter Miami | 🇺🇸USA | 19 | 13 | 1 | 0 | 6 | 6 | 40 |
| David Pereira da CostaAttacking midfielder |  Portland Timbers | 🇵🇹Portugal | 25 | 22 | 3 | 7 | 11.2 | 40▲21.3% | 45▼0.9% |
| Diego BorgesCentre-back |  Sporting Kansas City | 🇧🇷Brazil | 21 | 3 | 0 | 0 | 5.8 | 2 | 34 |
| Diego BorgesCentre-back | Sporting Kansas City | 🏳️ | 20 | 3 | 0 | 0 | 5.4 | 0 | 34 |
| E. AchouriCentral midfielder | San Diego | 🇹🇳Tunisia | 27 | 8 | 2 | 0 | 7 | 9▼57.1%↩ | 30▼14.2%↩ |
| E. AlladohCentre-forward | Philadelphia Union | 🇬🇭Ghana | 21 | 23 | 1 | 1 | 7 | 10▼65.4%↩ | 42▲10.9%↩ |
| E. AtuestaCentral midfielder |  Orlando City SC | 🇨🇴Colombia | 29 | 19 | 0 | 3 | 4.3 | 27▼18.5% | 27▼10.4% |
| E. BáezFull-back |  Atlanta United FC | 🇦🇷Argentina | 21 | 23 | 1 | 3 | 8.1 | 16▼76.6%↩ | 48▼18%↩ |
| E. BaillyCentre-back |  Columbus Crew | 🇨🇮Côte d'Ivoire | 32 | 2 | 0 | 0 | 0.8 | 1▼96.9%↩ | 11▼59%↩ |
| E. BoatengDefensive midfielder | San Diego | 🇬🇭Ghana | 32 | 13 | 0 | 0 | 0.9 | 3▼66%↩ | 12▼37.8%↩ |
| E. BushGoalkeeper | Columbus Crew | 🇺🇸USA | 40 | 6 | 0 | 0 | 0.3 | 3 | 6▲129.2% |
| E. CarliCentral midfielder | Seattle Sounders | 🏳️ | 18 | 1 | 0 | 0 | 5 | 0 | 35 |
| E. Choupo-MotingCentre-forward | New York Red Bulls | 🇨🇲Cameroon | 37 | 17 | 3 | 1 | 0.3 | 14▼76% | 4▼70.6% |
| E. DovloCentre-forward | Atlanta United FC | 🏳️ | 22 | 1 | 0 | 0 | 6.2 | 0 | 35 |
| E. EcheniqueAttacking midfielder |  FC Cincinnati | 🇻🇪Venezuela | 22 | 24 | 1 | 5 | 7.9 | 26▲282.1% | 44▲16.8% |
| E. EdwardsGoalkeeper | San Jose Earthquakes | 🇺🇸USA | 34 | 1 | 0 | 0 | 0.3 | 0▼100% | 6▼26% |
| E. EneliCentral midfielder | Real Salt Lake | 🇺🇸USA | 26 | 1 | 0 | 0 | 5.3 | 23▲20.7% | 38▲3.3% |
| E. FinlayCentral midfielder | Austin | 🇺🇸USA | 36 | 0 | 0 | 0 | 0.3 | 0▼100% | 5▼72.5% |
| E. ForsbergAttacking midfielder | New York Red Bulls | 🇸🇪Sweden | 34 | 23 | 3 | 4 | 1.4 | 32▼37.6% | 16▼11.5% |
| E. HoltCentre-back | Real Salt Lake | 🇺🇸USA | 30 | 0 | 0 | 0 | 1.5 | 0▼100% | 16▼55% |
| E. HorvathGoalkeeper | New York Red Bulls | 🇺🇸USA | 31 | 26 | 0 | 0 | 2.1 | 2▲242.9%↩ | 25▲1.2%↩ |
| E. IzoitaCentral midfielder | Portland Timbers | 🏳️ | 18 | 1 | 0 | 0 | 5.1 | 0 | 36 |
| E. KarićFull-back | Sporting Kansas City | 🇦🇹Austria | 29 | 11 | 0 | 2 | 2.9 | 7▼78.5%↩ | 23▼30%↩ |
| E. KohlerCentre-back | New England Revolution | 🏳️ | 20 | 18 | 0 | 0 | 7.3 | 25 | 46▲24.1%↩ |
| E. KohlerCentre-back | New England Revolution | 🇺🇸USA | 21 | 22 | 0 | 0 | 7.8 | 0 | 36▼2.2%↩ |
| E. LouroGoalkeeper | FC Cincinnati | 🇺🇸USA | 30 | 2 | 0 | 0 | 1.6 | 0▼100% | 17▼2.8% |
| E. LöwenAttacking midfielder | San Jose Earthquakes | 🇩🇪Germany | 29 | 15 | 3 | 2 | 2.4 | 0▼100%↩ | 22▼18.7%↩ |
| E. MihajCentre-back | Atlanta United FC | 🇦🇱Albania | 28 | 21 | 0 | 0 | 3.4 | 13▲225.6% | 30▲14.8% |
| E. MillerCentre-back | Portland Timbers | 🇺🇸USA | 33 | 5 | 0 | 0 | 0.6 | 1▼83.3% | 9▼2.2% |
| E. MoralesFull-back | CF Montreal | 🇧🇴Bolivia | 22 | 17 | 0 | 2 | 10 | 23▲100.9% | 43▲11.1% |
| É. OcampoFull-back |  Vancouver Whitecaps | 🇨🇴Colombia | 22 | 23 | 2 | 1 | 14.3 | 54▲45.8% | 50▲6.2% |
| E. PaniccoGoalkeeper | Nashville SC | 🇺🇸USA | 29 | 0 | 0 | 0 | 2 | 0▼100% | 19▼37.9% |
| E. SaadWinger | Nashville SC | 🇹🇳Tunisia | 26 | 9 | 0 | 3 | 6.8 | 10▲7.6%↩ | 33▼33.7%↩ |
| E. SabbiWinger | Vancouver Whitecaps | 🇺🇸USA | 28 | 20 | 4 | 3 | 5 | 29▼3.3% | 33▼4.1% |
| E. SeguraCentre-back | Los Angeles FC | 🇨🇴Colombia | 29 | 23 | 0 | 0 | 5.2 | 58▲53.3% | 31▲0.6% |
| E. TagsethDefensive midfielder | Nashville SC | 🇳🇴Norway | 25 | 21 | 1 | 0 | 7.5 | 24▼16% | 40▼5.2% |
| E. ThommyCentral midfielder |  Los Angeles Galaxy | 🇩🇪Germany | 32 | 16 | 1 | 0 | 1.4 | 11▼50.5%↩ | 14▼13.1%↩ |
| E. WynderCentral midfielder | Los Angeles Galaxy | 🇺🇸USA | 23 | 19 | 0 | 0 | 7.4 | 11▼24.8% | 39▲4% |
| Edward BerumenCentre-back | Los Angeles FC | 🇺🇸USA | 25 | 0 | 0 | 0 | 6.1 | 0 | 33 |
| Emilio Aristizábal ChavarriagaCentre-forward | Toronto FC | 🇨🇴Colombia | 21 | 19 | 4 | 0 | 7.1 | 15▼51.3%↩ | 42▲39.7%↩ |
| Eric IzoitaCentral midfielder | Portland Timbers | 🇺🇸USA | 19 | 1 | 0 | 0 | 5.3 | 0 | 36 |
| Ervin TorresAttacking midfielder | Austin | 🇺🇸USA | 18 | 13 | 1 | 2 | 7 | 12 | 41▲11.9% |
| EvanderWinger | FC Cincinnati | 🇧🇷Brazil | 28 | 24 | 12 | 8 | 6.9 | 73▲5.5% | 37▼2.4% |
| Ezequiel Abadia-RedaFull-back | Inter Miami | 🇺🇸USA | 20 | 4 | 0 | 0 | 5.7 | 1 | 36 |
| F. AmayaCentral midfielder | CF Montreal | 🇺🇸USA | 25 | 1 | 0 | 0 | 6 | 0▼100%↩ | 32▼14.7%↩ |
| F. BankCentre-forward | Toronto FC | 🏳️ | 23 | 1 | 0 | 0 | 6.3 | 0 | 34 |
| F. CaicedoCentre-back | Inter Miami | 🏳️ | 18 | 5 | 0 | 0 | 5.4 | 0 | 37 |
| F. CamaraCentral midfielder | Nashville SC | 🏳️ | 20 | 9 | 0 | 0 | 5.3 | 10 | 32 |
| F. FallCentre-back | St. Louis City | 🇸🇳Senegal | 22 | 9 | 1 | 0 | 7.7 | 3▼82.6%↩ | 39±0% |
| F. HerbersCentre-forward | CF Montreal | 🇩🇪Germany | 33 | 15 | 1 | 0 | 0.7 | 7▲34.7% | 11▲2.9% |
| F. MuraCentre-back | Inter Miami | 🇦🇷Argentina | 27 | 22 | 0 | 0 | 6.2 | 11▼58.6%↩ | 32▼20.3%↩ |
| F. NegriFull-back | Houston Dynamo | 🇦🇷Argentina | 31 | 14 | 1 | 0 | 2.1 | 17▲56.5%↩ | 18▼0.6%↩ |
| F. PicaultCentre-forward | Atlanta United FC | 🇭🇹Haiti | 35 | 18 | 3 | 1 | 0.9 | 18▲61.6%↩ | 10▲19.5%↩ |
